Reinforcing and phencyclidine-like stimulus properties of enantiomers of metazocine

  title={Reinforcing and phencyclidine-like stimulus properties of enantiomers of metazocine},
  author={Barbara L. Slifer and Robert L. Balster and Everette L. May},
  journal={Pharmacology Biochemistry and Behavior},
2 Citations

Locating Reward Cue at Response Manipulandum (CAM) Induces Symptoms of Drug Abuse

  • A. Tomie
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 1996

Trends in drug discrimination research analysed with a cross-indexed bibliography, 1984–1987

The drug discrimination procedure has become one of the most widely used paradigms in behavioural pharmacology, a situation which is reflected in the appearance to date of more 600 publications,



Phencyclidine-like discriminative effects of opioids in the rat.

  • S. Holtzman
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1980
Results provide further evidence that PCP and certain opioids share a common component of action that is probably mediated by neuronal substrates not usually associated with the activity of opioids.

Stereoisomers of N-allylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats.

(+/-)-N-Allylnormetazocine is a benzomorphan opioid with psychotomimetic effects. The pure stereoisomers of this compound, as well as the racemic mixture, were compared to phencyclidine for their

Pharmacological evaluation of N-allynormetazocine (SKF 10,047) on the basis of its discriminative stimulus properties in the rat.

  • H. Shannon
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1983
The present results demonstrate that the discriminative stimulus properties of NANM are distinguishable from those of morphine and ethylketazocine but similar to those of dissociative anesthetics such as phencyclidine and lend additional support to the hypothesis that sigma receptors mediate the common actions of N-allylnormetazocines and phen cyclidine.

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

It has been shown that buprenorphine is a partial agonist of the mu type which both suppressed and precipitated abstinence in the morphine-dependent dog while morphine and propoxyphene are stronger agonists.

Opioids: Similarity between evaluations of subjective effects and animal self‐administration results

Good concordance between the human and animal results further validates each procedure and suggests the possibility that both thehuman and animal procedures are measuring a common underlying pharmacological property which relates to abuse potential of drugs.