Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids.

@article{Young1984ReinforcingAD,
  title={Reinforcing and discriminative stimulus properties of mixed agonist-antagonist opioids.},
  author={Alice M. Young and Kenneth R. Stephens and David W Hein and J. H. Woods},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={229 1},
  pages={118-26}
}
Nine mixed agonist-antagonist opioids were evaluated in macaque monkeys for their ability to serve as positive reinforcers and for their discriminative stimulus similarity to etorphine and ethylketazocine. For tests of reinforcing properties, various doses of each drug were substituted for codeine under a fixed-ratio 30 time-out 600 sec schedule of i.v. delivery. Discriminative properties were assessed in separate groups of monkeys for which etorphine and saline, or ethylketazocine and saline… CONTINUE READING