Reinforcing and discriminative stimulus effects of beta-CIT in rhesus monkeys.

@article{Weed1995ReinforcingAD,
  title={Reinforcing and discriminative stimulus effects of beta-CIT in rhesus monkeys.},
  author={Michael R Weed and A S Mackevicius and John Kebabian and William L. Woolverton},
  journal={Pharmacology, biochemistry, and behavior},
  year={1995},
  volume={51 4},
  pages={953-6}
}
beta-CIT (also designated RTI-55) is one of a series of 2 beta-carbomethoxy-3 beta-phenyltropane cocaine analogues that have recently been synthesized for characterizing the dopamine transporter and its function. The present study was designed to examine the behavioral effects of beta-CIT in rhesus monkeys. Two monkeys were allowed to self-administer cocaine (0.01 or 0.03 mg/kg/inj, IV, fixed-ratio 10, 1 h/day) in baseline sessions. When behavior was stable, beta-CIT (0.0007-0.003 mg/kg/inj, IV… CONTINUE READING

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