Reinforcing and aversive effects of caffeine measured by flavor preference conditioning in caffeine-naive and caffeine-acclimated rats

@article{Myers2006ReinforcingAA,
  title={Reinforcing and aversive effects of caffeine measured by flavor preference conditioning in caffeine-naive and caffeine-acclimated rats},
  author={Kevin P Myers and Emily V. Izbicki},
  journal={Physiology & Behavior},
  year={2006},
  volume={88},
  pages={585-596}
}
Literature on the stimulus properties of caffeine in rats and humans has described both reinforcing and aversive effects. But some disagreement exists regarding whether caffeine is an effective positive reinforcer for caffeine-naive individuals, and how its stimulus properties change with habitual consumption. These experiments measured the reinforcing/aversive effects of caffeine for rats across a range of concentrations, assayed by conditioned aversion or preference for caffeine-paired… CONTINUE READING
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