Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms

  title={Reinforcing Strength of a Novel Dopamine Transporter Ligand: Pharmacodynamic and Pharmacokinetic Mechanisms},
  author={William L. Woolverton and Robert Ranaldi and Z Wang and Gregory A. Ordway and Ian A. Paul and Pavel A. Petukhov and Alan P. Kozikowski},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={211 - 217}
Drugs that block dopamine uptake often function as positive reinforcers but can differ along the dimension of strength or effectiveness as a positive reinforcer. The present study was designed to examine pharmacological mechanisms that might contribute to differences in reinforcing strength between the piperidine-based cocaine analog (+)-methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3-α-carboxylate [(+)-CPCA] and cocaine. Drugs were made available to rhesus monkeys (n = 5) for i.v. self… 

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