Reinforcing Effects Of Compounds Lacking Intrinsic Efficacy At α1 Subunit-Containing GABAA Receptor Subtypes in Midazolam- But Not Cocaine-Experienced Rhesus Monkeys

@article{Shinday2013ReinforcingEO,
  title={Reinforcing Effects Of Compounds Lacking Intrinsic Efficacy At $\alpha$1 Subunit-Containing GABAA Receptor Subtypes in Midazolam- But Not Cocaine-Experienced Rhesus Monkeys},
  author={Nina M. Shinday and E. Sawyer and B. Fischer and D. M. Platt and S. C. Licata and J. Atack and G. Dawson and D. Reynolds and J. K. Rowlett},
  journal={Neuropsychopharmacology},
  year={2013},
  volume={38},
  pages={1006-1014}
}
Benzodiazepines are prescribed widely but their utility is limited by unwanted side effects, including abuse potential. The mechanisms underlying the abuse-related effects of benzodiazepines are not well understood, although α1 subunit-containing GABAA receptors have been proposed to have a critical role. Here, we examine the reinforcing effects of several compounds that vary with respect to intrinsic efficacy at α2, α3, and α5 subunit-containing GABAA receptors but lack efficacy at α1 subunit… Expand
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