Reindeer bone extract can heal the critical-size rat femur defect

@article{Tlli2010ReindeerBE,
  title={Reindeer bone extract can heal the critical-size rat femur defect},
  author={Hanna T{\"o}lli and Sauli Kujala and Timo J{\"a}ms{\"a} and P. K. A. Jalovaara},
  journal={International Orthopaedics},
  year={2010},
  volume={35},
  pages={615-622}
}
Bone extract from reindeer induces new ectopic bone formation (BF) in muscle pouches, but its feasibility in experimental bone lesions has not been evaluated. We investigated the effects of implants, containing 2, 5, 15, 20 or 50 mg of reindeer bone extract in a collagen carrier, on the healing of 8-mm femur defects in 78 rats. We used 30 µg of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a collagen carrier, collagen and untreated defects as controls. Bone healing was evaluated… CONTINUE READING