Reincarnation of ancient links between coagulation and complement.

@article{Conway2015ReincarnationOA,
  title={Reincarnation of ancient links between coagulation and complement.},
  author={Edward M Conway},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2015},
  volume={13 Suppl 1},
  pages={S121-32}
}
Throughout evolution, organisms have developed means to contain wounds by simultaneously limiting bleeding and eliminating pathogens and damaged host cells via the recruitment of innate defense mechanisms. Disease emerges when there is unchecked activation of innate immune and/or coagulation responses. A key component of innate immunity is the complement system. Concurrent excess activation of coagulation and complement - two major blood-borne proteolytic pathways - is evident in numerous… CONTINUE READING
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