Rehabilitative Training Tasks Improve Spatial Learning Impairment in the Water Maze Following Hypoxic-Ischemic Insult in Neonatal Rats

@article{Ikeda2006RehabilitativeTT,
  title={Rehabilitative Training Tasks Improve Spatial Learning Impairment in the Water Maze Following Hypoxic-Ischemic Insult in Neonatal Rats},
  author={Tomoaki Ikeda and Kenichi Mishima and Naoya Aoo and Kazuhiko Harada and An Xin Liu and Nobuaki Egashira and Katsunori Iwasaki and Michihiro Fujiwara and Tsuyomu Ikenoue},
  journal={Pediatric Research},
  year={2006},
  volume={59},
  pages={61-65}
}
We recently reported that hypoxic-ischemic (HI) insult to the brain of 7-d-old rats resulted in a slowly progressive learning and memory disability, which started at around 5 wk after HI, a time frame that is representative of human adolescence. The purpose of the present study was to examine whether physical or mental exercises can prevent this late-onset, slowly progressing disability. Wistar rats were subjected to left carotid ligation followed by 2 h of hypoxic stress (8% O2 and 92% N2 at… CONTINUE READING

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