Regulatory sites in the melatonin system of mammals.

  title={Regulatory sites in the melatonin system of mammals.},
  author={Diana N. Krause and Margarita L Dubocovich},
  journal={Trends in neurosciences},
  volume={13 11},
The hormone melatonin was first identified about 30 years ago as a secretory product of the pineal gland. In mammals, the daily rhythm of pineal melatonin synthesis is controlled by neural inputs. The CNS is thought to be a primary target organ involved in mediating the influence of melatonin on a variety of physiological and behavioral processes, including biological rhythms, neuroendocrine function, activity levels and sleep. It now appears that melatonin is also produced in the retina and… CONTINUE READING
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