Regulatory roles for L-arginine in reducing white adipose tissue.

  title={Regulatory roles for L-arginine in reducing white adipose tissue.},
  author={Bie Tan and Xinguo Li and Yulong Yin and Zhenlong Wu and Chuang Liu and Carmen D. Tekwe and Guoyao Wu},
  journal={Frontiers in bioscience},
As the nitrogenous precursor of nitric oxide, L-arginine regulates multiple metabolic pathways involved in the metabolism of fatty acids, glucose, amino acids, and proteins through cell signaling and gene expression. Specifically, arginine stimulates lipolysis and the expression of key genes responsible for activation of fatty acid oxidation to CO2 and water. The underlying mechanisms involve increases in the expression of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha… CONTINUE READING
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Dietary arginine supplementation differentially regulates expression of fat-metabolic genes in porcine adipose tissue and skeletal muscle

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