Regulatory role of translocation of Na+-K+ pumps in skeletal muscle: hypothesis or reality?

@article{Clausen2008RegulatoryRO,
  title={Regulatory role of translocation of Na+-K+ pumps in skeletal muscle: hypothesis or reality?},
  author={T. Clausen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={295 3},
  pages={
          E727-8; author reply 729
        }
}
  • T. Clausen
  • Published 2008
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
to the editor: The Perspectives article by Benziane and Chibalin ([1][1]) in this issue comments on part of the literature regarding the possible role of translocation in the regulation of Na+-K+ pumps in skeletal muscle. I have been invited to submit a letter to the editor about this review article 
Reply to Clausen letter
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The skeletal muscle sodium pump plays a major role in the removal of K(+) ions from the circulation postprandial, or after a physical activity bout, thereby preventing the development of hyperkalemiaExpand
Active Na—K transport and the rate of ouabain binding. The effect of insulin and other stimuli on skeletal muscle and adipocytes
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The effect of stimulation or inhibition of active Na—K transport on [3H]ouabain binding has been investigated in isolated soleus muscles and adipocytes and the results confirmed the importance of knowing the carrier and removal status of Na-K in the transport of H2O. Expand
Na+-K+ pump regulation and skeletal muscle contractility.
  • T. Clausen
  • Chemistry, Medicine
  • Physiological reviews
  • 2003
TLDR
The Na+-K+ pump is a central target for regulation of Na-k+ distribution and excitability, essential for second-to-second ongoing maintenance of excitability during work. Expand
The number of sodium ion pumping sites in skeletal muscle and its modification by insulin.
TLDR
It is concluded that there are two pools of Na pumping sites in muscle cells: one active and another inactive, and insulin unmasks the inactive pumping sites by a mechanism that is independent of protein synthesis, increases in intracellular [Na] or decreases in intrACEllular [K]. Expand
Quantitative determination of Na+-K+-ATPase and other sarcolemmal components in muscle cells.
TLDR
Recent studies have shown that regulatory changes in the entire population of Na+-K+ pumps in muscle can be quantified in measurements of [3H]-ouabain binding, K+-activated 3-O-methylfluorescein phosphatase activity, as well as maximum ouabain suppressible Na-k+ transport capacity. Expand
Ouabain binding and Na+K+ transport in rat muscle cells and adipocytes
Abstract 1. 1. The accumulation and the release of [3H]ouabain has been characterized in isolated intact soleus muscles and free fat cells of the rat. The number of ouabain-binding sites wasExpand
AMPK activation with AICAR provokes an acute fall in plasma [K+].
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It is illustrated that activation of AMPK activity with AICAR provokes a significant fall in plasma [K(+)] and a novel mechanism for redistributing K(+) from ECF to ICF is suggested. Expand
The effect of insulin on the transport of sodium and potassium in rat soleus muscle.
TLDR
It is concluded that insulin stimulates the active coupled transport of Na and K, possibly by increasing the relative Na‐affinity of the system mediating this process. Expand
Analysis of exercise‐induced Na+–K+ exchange in rat skeletal muscle in vivo
TLDR
In the soleus, in vivo exercise induces a rise in intracellular Na+, which reflects the excitation‐induced increase in Na+ influx and leads to augmented Na+–K+ pump activity without apparent change in Na+, and there was no effect of exercise on [3H]ouabain binding measured in vitro or in vivo. Expand
Cardiotonic Steroids Stimulate Glycogen Synthesis in Human Skeletal Muscle Cells via a Src- and ERK1/2-dependent Mechanism*
TLDR
Ouabain and marinobufagenin stimulate glycogen synthesis in skeletal muscle cells and this effect is mediated by activation of a Src-, ERK1/2, p90rsk-, and GSK3-dependent signaling pathway. Expand