Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.

@article{Lpez2014RegulatoryRO,
  title={Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.},
  author={Juan Pablo Maldonado L{\'o}pez and Laura M. Fiori and Jeffrey A. Gross and Benoit Labont{\'e} and Volodymyr Yerko and Naguib Mechawar and Gustavo Turecki},
  journal={The international journal of neuropsychopharmacology},
  year={2014},
  volume={17 1},
  pages={23-32}
}
MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in the post-transcriptional regulation of mRNA. These molecules have been the subject of growing interest as they are believed to control the regulation of a large number of genes, including those expressed in the brain. Evidence suggests that miRNAs could be involved in the pathogenesis of neuropsychiatric disorders. Alterations in metabolic enzymes of the polyamine system have been reported to play a role in… CONTINUE READING

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