Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.

@article{Ino2004RegulatoryRO,
  title={Regulatory role of membrane-bound peptidases in the progression of gynecologic malignancies.},
  author={Kazuhiko Ino and Kiyosumi Shibata and Hiroaki Kajiyama and Fumitaka Kikkawa and Shigehiko Mizutani},
  journal={Biological chemistry},
  year={2004},
  volume={385 8},
  pages={683-90}
}
Membrane-bound peptidases play a key role in the control of growth, differentiation, and signal transduction of many cellular systems by degrading bioactive peptides. Thus, abnormal changes in their expression pattern and catalytic function result in altered peptide activation, which contributes to neoplastic transformation or progression. In this review, we describe our recent findings along with work from other groups on the expression and biological functions of membrane-bound peptidases in… CONTINUE READING
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