Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing.

@article{Sato1999RegulatoryRO,
  title={Regulatory role of endogenous interleukin-10 in cutaneous inflammatory response of murine wound healing.},
  author={Yuki Sato and Tohru Ohshima and Toshikazu Kondo},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={265 1},
  pages={194-9}
}
This study investigated the role of endogenous interleukin (IL)-10 in cutaneous wound healing. Both IL-10 mRNA and protein were detectable in murine incised wounds for 10 days after injury. The IL-10 protein level peaked 3 h after incision, returned to the normal level by 24 h, but increased again to another peak at 72 h. In situ hybridization studies and immunostaining revealed that epidermal cells and infiltrating mononuclear cells were the major source of IL-10. Neutralizing antibody studies… CONTINUE READING

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