Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.

@article{Kato1995RegulatoryRO,
  title={Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.},
  author={Isao Kato and Shin Takasawa and Ayumu Akabane and Osamu Tanaka and Hiroshi Abe and Toshinari Takamura and Yasuyuki Suzuki and Koji Nata and Hideto Yonekura and Takayuki Yoshimoto},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 50},
  pages={
          30045-50
        }
}
Cyclic ADP-ribose (cADPR) serves as a second messenger for Ca2+ mobilization in insulin secretion, and CD38 has both ADP-ribosyl cyclase and cADPR hydrolase activities (Takasawa, S., Tohgo, A., Noguchi, N., Koguma, T., Nata, K., Sugimoto, T., Yonekura, H., and Okamoto, H. (1993) J. Biol. Chem. 268, 26052-26054). Here, we produced transgenic mice overexpressing human CD38 in pancreatic beta cells. The enzymatic activity of CD38 in transgenic islets was greatly increased, and ATP efficiently… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Similar Papers

Loading similar papers…