Regulatory role for GTP-binding proteins in endocytosis.

@article{Mayorga1989RegulatoryRF,
  title={Regulatory role for GTP-binding proteins in endocytosis.},
  author={Luis S. Mayorga and Raquel Diaz and Philip D. Stahl},
  journal={Science},
  year={1989},
  volume={244 4911},
  pages={1475-7}
}
Guanosine 5'-triphosphate (GTP)-binding proteins have been implicated in the transport of newly synthesized proteins along the secretory pathway of yeast and mammalian cells. Early vesicle fusion events that follow receptor-mediated endocytosis as measured by three in vitro assays were blocked by guanosine 5'-O-(3-thiotriphosphate) and aluminum fluoride. The effect was specific for guanosine nucleotides and depended on the presence of cytosolic factors. Thus, GTP-binding proteins may also have… CONTINUE READING

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