Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia.

Abstract

The aim of this study is to determine whether the polymorphisms of the MDR1 gene are associated with the development of childhood acute lymphoblastic leukemia (ALL). The MDR1 gene polymorphisms, -2352 G>A, -934A>G, -692T>C (5' regulatory region) and 3435C>T (exon 26), were examined in 157 ALL patients and 96 healthy children. The amounts of MDR1 mRNA were… (More)

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@article{Hattori2007RegulatoryPO, title={Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia.}, author={Hiroyoshi Hattori and Aiko Suminoe and Morimasa Wada and Yuhki Koga and Kimitoshi Kohno and Jun Okamura and Toshiro Hara and Akinobu Matsuzaki}, journal={Leukemia research}, year={2007}, volume={31 12}, pages={1633-40} }