Regulatory polymorphisms in CYP2C19 affecting hepatic expression.

Abstract

BACKGROUND Cytochrome P450 2C19 is responsible for the metabolism of many drugs, including the activation of clopidogrel. The allele CYP2C19*17 is associated with ultra-rapid metabolizer phenotypes by increasing gene transcription. This study tests to what extent CYP2C19*17 enhances CYP2C19 expression in human liver and whether additional regulatory… (More)
DOI: 10.1515/dmdi-2012-0038

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