Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy.

@article{LeandroGarca2012RegulatoryPI,
  title={Regulatory polymorphisms in β-tubulin IIa are associated with paclitaxel-induced peripheral neuropathy.},
  author={Luis Javier Leandro-Garc{\'i}a and Susanna Leskel{\"a} and C Jara and Henrik Gr{\'e}en and Elisabeth {\AA}vall-Lundqvist and Heather E Wheeler and M. Eileen Dolan and Luc{\'i}a Inglada-P{\'e}rez and Agnieszka Maliszewska and Aguirre A de Cubas and I{\~n}aki Comino-M{\'e}ndez and Veronika Man{\vc}{\'i}kov{\'a} and Alberto Casc{\'o}n and Mercedes Robledo and Cristina Rodr{\'i}guez-Antona},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2012},
  volume={18 16},
  pages={4441-8}
}
PURPOSE Peripheral neuropathy is the dose-limiting toxicity of paclitaxel, a chemotherapeutic drug widely used to treat several solid tumors such as breast, lung, and ovary. The cytotoxic effect of paclitaxel is mediated through β-tubulin binding in the cellular microtubules. In this study, we investigated the association between paclitaxel neurotoxicity risk and regulatory genetic variants in β-tubulin genes. EXPERIMENTAL DESIGN We measured variation in gene expression of three β-tubulin… CONTINUE READING
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