Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.

@article{Yamada2013RegulatoryPI,
  title={Regulatory phosphorylation induces extracellular conformational changes in a CLC anion channel.},
  author={Toshiki Yamada and Manasi P. Bhate and K. Strange},
  journal={Biophysical journal},
  year={2013},
  volume={104 9},
  pages={
          1893-904
        }
}
CLH-3b is a CLC-1/2/Ka/Kb channel homolog activated by meiotic cell cycle progression and cell swelling. Channel inhibition occurs by GCK-3 kinase-mediated phosphorylation of serine residues on the cytoplasmic C-terminus linker connecting CBS1 and CBS2. Two conserved aromatic amino acid residues located on the intracellular loop connecting membrane helices H and I and α1 of CBS2 are required for transducing phosphorylation changes into changes in channel activity. Helices H and I form part of… Expand
ClC-2 Chloride Channels
CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease.
WNK Kinases in Development and Disease.

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