Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC

@article{Taniguchi2007RegulatoryMI,
  title={Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC},
  author={Shun’ichiro Taniguchi and Junji Sagara},
  journal={Seminars in Immunopathology},
  year={2007},
  volume={29},
  pages={231-238}
}
The recent identification of cytosolic pattern recognition receptors (PRRs) with leucine-rich repeats, which recognize pathogen-associated molecular patterns (PAMPs), has been garnering considerable attention. Activated PRRs form molecular complexes called inflammasomes, consisting of related proteins that include procaspase 1[interleukin (IL) 1β converting enzyme (ICE)]. Inflammasomes have been shown to facilitate molecular proximity, stimulate activation of procaspase 1, which consequently… CONTINUE READING

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