Regulatory mechanisms of microRNAs involvement in cancer.

  title={Regulatory mechanisms of microRNAs involvement in cancer.},
  author={Muller Fabbri and Mircea Ivan and Amelia Cimmino and Massimo Negrini and George A. Calin},
  journal={Expert opinion on biological therapy},
  volume={7 7},
MicroRNAs (miRNAs) are 19-24 nucleotide noncoding RNAs that regulate the translation and degradation of target mRNAs and are extensively involved in human cancers. One unexpected conclusion of the profiling and functional studies in tumourigenesis is that some miRNAs behave in cancer cells in a dual mode, resembling the 'Dr Jekyll and Mr Hyde' story, which centers on a conception of humanity as dual in nature. The authors and others have found that onco-miRNAs and suppressor-miRNAs can… CONTINUE READING

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