Regulatory mechanisms of immune responses to intestinal bacteria

  title={Regulatory mechanisms of immune responses to intestinal bacteria},
  author={Kenya Honda and Kiyoshi Takeda},
  journal={Mucosal Immunology},
The intestinal mucosa allows the residence of trillions of bacteria with which it interacts dynamically. To establish and maintain a mutually beneficial relationship, the mucosal immune system must enforce tolerance toward the vast non-pathogenic microbiota while simultaneously remaining reactive to potentially pathogenic microbes; the disruption of this delicate balance results in inflammatory bowel diseases. In this review, we describe advances in our understanding of regulatory mechanisms of… CONTINUE READING

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