Regulatory mechanisms of betacellulin in CXCL8 production from lung cancer cells

Abstract

Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, binds and activates ErbB1 and ErbB4 homodimers. BTC was expressed in tumors and involved in tumor growth progression. CXCL8 (interleukin-8) was involved in tumor cell proliferation via the transactivation of the epidermal growth factor receptor (EGFR). The present study was designed… (More)
DOI: 10.1186/1479-5876-12-70

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