Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis

@inproceedings{Besschetnova2015RegulatoryMO,
  title={Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis},
  author={Tatiana Y. Besschetnova and Takaharu Ichimura and Negin Katebi and Brad St. Croix and Joseph V. Bonventre and Bj{\o}rn R. Olsen},
  booktitle={Matrix biology : journal of the International Society for Matrix Biology},
  year={2015}
}
It is well known that angiogenesis is linked to fibrotic processes in fibroproliferative diseases, but insights into pathophysiological processes are limited, due to lack of understanding of molecular mechanisms controlling endothelial and fibroblastic homeostasis. We demonstrate here that the matrix receptor anthrax toxin receptor 1 (ANTXR1), also known as tumor endothelial marker 8 (TEM8), is an essential component of these mechanisms. Loss of TEM8 function in mice causes reduced synthesis of… CONTINUE READING

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