Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells.

@article{Lee2007RegulatoryMO,
  title={Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells.},
  author={Y. J. Lee and Ho Jae Han},
  journal={Kidney international. Supplement},
  year={2007},
  volume={106},
  pages={S27-35}
}
Glucose is a key fuel and an important metabolic substrate in mammals. Renal proximal tubular cells (PTCs) not only reabsorb filtered glucose but are also believed to play a role in the glucotoxicity associated with renal pathogenesis, such as in diabetes. The proximal tubule environment is where 90% of the filtered glucose is reabsorbed by the low-affinity/high-capacity Na(+)/glucose cotransporter 2 (SGLT2) and facilitated diffusion glucose transporter 2 (GLUT2). Both active and facilitative… CONTINUE READING
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