Regulatory mechanisms of AMPA receptors in synaptic plasticity

  title={Regulatory mechanisms of AMPA receptors in synaptic plasticity},
  author={Victor A. Derkach and Michael C. Oh and Eric S. Guire and Thomas R. Soderling},
  journal={Nature Reviews Neuroscience},
Activity-dependent changes in the strength of excitatory synapses are a cellular mechanism for the plasticity of neuronal networks that is widely recognized to underlie cognitive functions such as learning and memory. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) are the main transducers of rapid excitatory transmission in the mammalian CNS, and recent discoveries indicate that the mechanisms which regulate AMPARs are more complex than previously… CONTINUE READING
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AMPA receptors trading places

  • J. A. Kauer, Malenka, R. C. LTP
  • Nature Neurosci. 9, 593–594
  • 2006

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