Regulatory mechanisms and functions of MAP kinase signaling pathways.

  title={Regulatory mechanisms and functions of MAP kinase signaling pathways.},
  author={Masamichi Imajo and Yoshiki Tsuchiya and Eisuke Nishida},
  journal={IUBMB life},
  volume={58 5-6},
Mitogen-activated protein kinase (MAPK) pathways play central roles in controlling diverse cellular functions. They are finely regulated by several mechanisms, including scaffolding of their components, and phosphorylation/dephosphorylation and compartmentalization of MAPKs. A number of molecules have been identified as regulators involved in these mechanisms. They modulate the magnitude and the specificity of MAPK signaling, and thereby regulate the wide variety of signaling outputs. Recent… CONTINUE READING