Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome

@inproceedings{Cannizzaro2017RegulatoryLO,
  title={Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome},
  author={Luca Cannizzaro and Giuseppe Rossoni and Federica Savi and Alessandra A. Altomare and Cristina Marinello and Thammakorn Saethang and Marina Carini and D. Michael Payne and Trairak Pisitkun and Giancarlo Aldini and Asada Leelahavanichkul},
  booktitle={Nutrition & metabolism},
  year={2017}
}
BACKGROUND The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPARγ activation is known to modulate metabolic syndrome; however a systems-level investigation looking at the protective effects of PPARγ activation as related to the AROS axis has not been performed. The aim of this work is to simultaneously characterize multiple molecular parameters within the AROS axis, using samples taken from different… CONTINUE READING
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