Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm

@article{Howard1986RegulatoryIB,
  title={Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm},
  author={K. R. Howard and Philip W. Ingham},
  journal={Cell},
  year={1986},
  volume={44},
  pages={949-957}
}

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

It is proposed that the precise positioning of the en stripes depends upon signals generated in a combinatorial manner by the overlaps between the ftz or eve domains and those of other pair rule genes, specifically odd paired, opa and paired, prd11,16,17.

The pattern of cell death in fushi tarazu, a segmentation gene of Drosophila.

There is cell death in the pair-rule mutant which begins at the completion of germ band extension, and cell death is not limited to those cells that would normally express ftz+, suggesting that it is some indirect consequence of the abnormal situation in the mutant embryo.

Mis-regulating segmentation gene expression in Drosophila.

It is shown that fusion gene expression is transcriptionally regulated, such that ectopic expression is suppressed when pattern is established, and evidence indicating that interstripe hb-ftz expression is repressed by eve is presented.

Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis.

Fushi tarazu (ftz), amentation genes control cell identities during early pattern formation in Drosophila, is now shown also to control cell fate during neurogenesis.

fushi tarazu protein expression in the cellular blastoderm of Drosophila detected using a novel imaging technique.

Novel intermediate patterns of ftz protein expression which were detected in younger embryos by using anti-ftz antibodies and a sensitive fluorescence/immunoperoxidase technique ('filtered fluorescence imaging', FFI) are described.

Region-specific alleles of the Drosophila segmentation gene hairy.

This paper describes four regulatory hairy mutations using in situ hybridization and shows that these mutations cause alterations in the normal pattern of hairy expression, suggesting that a major function of hairy is to decode a prepattern consisting of complex cues into a simple periodic pattern.

Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo.

The Drosophila pair-rule segmentation gene, hairy, is demonstrated to be localized to the nuclei of cells in eight distinct regions of the early embryo, indicating that hairy plays a direct role in repressing ftz gene expression.
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References

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Transcription pattern of the Drosophila segmentation gene hairy

It is found that transcripts of one pair-rule gene, hairy, accumulate in eight distinct regions of the early embryo, and this pattern of expression is compared with that of another pair- rule gene, fushi tarazu, and its dependence on maternally expressed genes is described.

Segments, Lineage Boundaries and the Domains of Expression of Homeotic Genes

It is suggested that during formation of the germ band, the abundance of Ultrabithorax transcripts shows a transient segment ‘pair-rule’ modulation, which reflects an interaction between the Ultrabitorax gene and a segment pair-rule function, which may serve to establish the precise correlation between lineage boundaries and the domains of ultrabithOrax expression.

Cloning sequences from the hairy gene of Drosophila.

To study the function of this gene at a molecular level, sequences from the hairy locus were cloned and the hairy1 (h1) mutation, which is caused by the insertion of the transposable element, gypsy, was facilitated.

Developmental compartmentalisation of the wing disk of Drosophila.

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A gene complex controlling segmentation in Drosophila

The wild-type and mutant segmentation patterns are consistent with an antero-posterior gradient in repressor concentration along the embryo and a proximo-distal gradient along the chromosome in the affinities for repressor of each gene's cis-regulatory element.