Regulatory interactions between the amino terminus of G-protein βγ subunits and the catalytic domain of phospholipase Cβ2

@inproceedings{Bonacci2005RegulatoryIB,
  title={Regulatory interactions between the amino terminus of G-protein βγ subunits and the catalytic domain of phospholipase Cβ2},
  author={Tabetha M. Bonacci and Mousumi Ghosh and Sundeep Malik and Alan V. Smrcka},
  year={2005}
}
Abstract We previously identified a 10-amino acid region from the Y domain of phospholipase Cβ2 (PLCβ2) that associates with G-protein βγ subunits (Sankaran, B., Osterhout, J., Wu, D., and Smrcka, A. V. (1998) J. Biol. Chem. 273, 7148–7154). We mapped the site for cross-linking of a synthetic peptide (N20K) corresponding to this Y domain region to Cys25 within the amino-terminal coiled-coil domain of Gβγ (Yoshikawa, D. M., Bresciano, K., Hatwar, M., and Smrcka, A. V. (2001) J. Biol. Chem. 276… CONTINUE READING

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