Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase.

@article{Temel2013RegulatoryIB,
  title={Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase.},
  author={Deniz B Temel and Kaushik Dutta and S{\'e}bastien Alphonse and Julien Nourikyan and Christophe Grangeasse and Ranajeet Ghose},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 21},
  pages={
          15212-28
        }
}
The cyclic process of autophosphorylation of the C-terminal tyrosine cluster (YC) of a bacterial tyrosine kinase and its subsequent dephosphorylation following interactions with a counteracting tyrosine phosphatase regulates diverse physiological processes, including the biosynthesis and export of polysaccharides responsible for the formation of biofilms or virulence-determining capsules. We provide here the first detailed insight into this hitherto uncharacterized regulatory interaction at… CONTINUE READING
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