Regulatory interactions between RNA and polycomb repressive complex 2.

  title={Regulatory interactions between RNA and polycomb repressive complex 2.},
  author={Catherine Cifuentes-Rojas and Alfredo J. Hernandez and Kavitha Sarma and Jeannie T Lee},
  journal={Molecular cell},
  volume={55 2},
Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that is localized to thousands of mammalian genes. Though important to human disease and as a drug target, how PRC2 is recruited remains unclear. One model invokes cis-regulatory RNA. Herein, we biochemically and functionally probe PRC2's recognition of RNA using the X-inactivation model. We observe surprisingly high discriminatory capabilities. While SUZ12 and JARID2 subunits can bind RNA, EZH2 has highest affinity and is… CONTINUE READING
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