Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell- mediated immunity

@article{Powrie1994RegulatoryIB,
  title={Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell- mediated immunity},
  author={Fiona Powrie and Rodrigo Corr{\^e}a-Oliveira and Smita Mauze and Robert Lee Coffman},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={179},
  pages={589 - 600}
}
BALB/c mice infected with the intracellular protozoan Leishmania major mount a T helper cell 2 (Th2) response that fails to control growth of the parasite and results in the development of visceral leishmaniasis. Separation of CD4+ T cells into CD45RBhigh and CD45RBlow subsets showed that the L. major-specific Th2 cells were contained within the CD45RBlow population as these cells produced high levels of antigen-specific interleukin 4 (IL-4) in vitro and transferred a nonhealing response to L… CONTINUE READING
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