Regulatory influence of melatonin on collagen accumulation in the infarcted heart scar.

@article{Drobnik2008RegulatoryIO,
  title={Regulatory influence of melatonin on collagen accumulation in the infarcted heart scar.},
  author={Jacek Drobnik and Małgorzata Karbownik-Lewińska and Alicja Szczepanowska and Donata Słotwińska and Sławomir Olczak and Lucjusz Jakubowski and Ryszard Dabrowski},
  journal={Journal of pineal research},
  year={2008},
  volume={45 3},
  pages={285-90}
}
The regulatory influence of the pineal gland on superficial wound healing and collagen content is documented. The aim of the present study was to determine whether the pineal gland and its secretory product melatonin regulate collagen accumulation in the scar of the infarcted heart and to explain the mechanisms of its action. To induce myocardial infarction in rats the left coronary artery was ligated. Metoprolol at the dose of 0.2 mg/100 g body weight (b.w.) was injected intraperitoneally to… CONTINUE READING

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