Regulatory function of the Saccharomyces cerevisiae RAS C-terminus.

  title={Regulatory function of the Saccharomyces cerevisiae RAS C-terminus.},
  author={Mark S. Marshall and Jackson B. Gibbs and Edward M. Scolnick and Irving S. Sigal},
  journal={Molecular and cellular biology},
  volume={7 7},
Activating mutations (valine 19 or leucine 68) were introduced into the Saccharomyces cerevisiae RAS1 and RAS2 genes. In addition, a deletion was introduced into the wild-type gene and into an activated RAS2 gene, removing the segment of the coding region for the unique C-terminal domain that lies between the N-terminal 174 residues and the penultimate 8-residue membrane attachment site. At low levels of expression, a dominant activated phenotype, characterized by low glycogen levels and poor… CONTINUE READING

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