Regulatory function of CD4+CD25+ T cells from Class II MHC-deficient mice in contact hypersensitivity responses.

@article{Kish2007RegulatoryFO,
  title={Regulatory function of CD4+CD25+ T cells from Class II MHC-deficient mice in contact hypersensitivity responses.},
  author={Danielle D. Kish and Anton V. Gorbachev and R. L. Heckaman Mark D. Fairchild},
  journal={Journal of leukocyte biology},
  year={2007},
  volume={82 1},
  pages={
          85-92
        }
}
Contact hypersensitivity (CHS) is a CD8+ T cell-mediated, inflammatory response to hapten sensitization and challenge of the skin. During sensitization, the magnitude and duration of hapten-specific CD8+ T cell expansion in the skin-draining lymph nodes (LN) are restricted by CD4+CD25+ T regulatory cells (Treg). The regulation of hapten-specific CD8+ T cell priming in Class II MHC-deficient (MHC-/-) mice was investigated. Although hapten-specific CD8+ T cell priming and CHS responses were… CONTINUE READING
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