Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB

@article{Lynch2011RegulatoryET,
  title={Regulatory evolution through divergence of a phosphoswitch in the transcription factor CEBPB},
  author={Vincent J. Lynch and Gemma May and G{\"u}nter P. Wagner},
  journal={Nature},
  year={2011},
  volume={480},
  pages={383-386}
}
There is an emerging consensus that gene regulation evolves through changes in cis-regulatory elements and transcription factors. Although it is clear how nucleotide substitutions in cis-regulatory elements affect gene expression, it is not clear how amino-acid substitutions in transcription factors influence gene regulation. Here we show that amino-acid changes in the transcription factor CCAAT/enhancer binding protein-β (CEBPB, also known as C/EBP-β) in the stem-lineage of placental mammals… CONTINUE READING
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