Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites.

@article{Moses2007RegulatoryEI,
  title={Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites.},
  author={Alan M. Moses and Muluye E. Liku and Joachim J. Li and Richard Durbin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 45},
  pages={17713-8}
}
Evolutionary change in gene regulation is a key mechanism underlying the genetic component of organismal diversity. Here, we study evolution of regulation at the posttranslational level by examining the evolution of cyclin-dependent kinase (CDK) consensus phosphorylation sites in the protein subunits of the pre-replicative complex (RC). The pre-RC, an assembly of proteins formed during an early stage of DNA replication, is believed to be regulated by CDKs throughout the animals and fungi… CONTINUE READING

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