Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures.

Abstract

Insulin-like growth factors I and II (IGF-I and -II) are polypeptides secreted by skeletal cells and are considered regulators of bone formation. IGF-I and -II were studied for their effects on collagen synthesis and degradation in cultures of intact fetal rat calvariae and on type I collagen transcript levels in osteoblast-enriched (Ob) cells from fetal… (More)

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@article{McCarthy1989RegulatoryEO, title={Regulatory effects of insulin-like growth factors I and II on bone collagen synthesis in rat calvarial cultures.}, author={Thomas L. McCarthy and Michael Centrella and Emilio Canal{\'i}s}, journal={Endocrinology}, year={1989}, volume={124 1}, pages={301-9} }