Regulatory effects of gastrin and secretin on carcinomas of the stomach and colon.

  title={Regulatory effects of gastrin and secretin on carcinomas of the stomach and colon.},
  author={J. Tanaka and T. Yamaguchi and Toshiyuki Takahashi and N. Ogata and K. Bando and K. Koyama},
  journal={The Tohoku journal of experimental medicine},
  volume={148 4},
Gastrin (10 micrograms/ml) enhanced 14C-leucine uptake in cultured tissue of stomach and colon carcinomas and content of 14C-labelled protein in the medium was increased. One of 2 stomach and one of 3 colon carcinomas transplanted into nude mice were enhanced in growth by pentagastrin injected in a dose of 250 micrograms/kg every day. On the other hand, secretin (100 U/kg) inhibited the trophic action of pentagastrin. 
The role of gastrin and cholecystokinin in normal and neoplastic gastrointestinal growth
  • G. Baldwin
  • Medicine
  • Journal of gastroenterology and hepatology
  • 1995
Growth-promoting effects of gastrin on mouse colon cancer cells in vitro: Absence of autocrine effects
Therapeutic achlorhydria and risk of gastric cancer
A study of the mechanism of butachlor-associated gastric neoplasms in Sprague-Dawley rats.
  • D. Thake, M. Iatropoulos, +4 authors A. Wilson
  • Biology, Medicine
  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 1995


New aspects of the trophic action of gastrointestinal hormones.