Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on inflammatory responses in psoriasis.

@article{Inoue1998RegulatoryEO,
  title={Regulatory effects of 1alpha,25-dihydroxyvitamin D3 on inflammatory responses in psoriasis.},
  author={Michitaka Inoue and Toshimitsu Matsui and Akiko Nishibu and Yoshiaki Nihei and Keiji Iwatsuki and Fumio Kaneko},
  journal={European journal of dermatology : EJD},
  year={1998},
  volume={8 1},
  pages={
          16-20
        }
}
Topical application of 1alpha,25-dihydroxyvitamin D3 (VD3) is thought to be beneficial in psoriasis because of its action in regulating keratinocyte proliferation and inflammation mediated by various cytokines. We assessed the effect of VD3 on the production levels of interferon (IFN)-alpha, interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-alpha in mitogen-stimulated peripheral blood mononuclear cells (PBMC) of psoriatic patients. The results demonstrated that VD3 significantly… CONTINUE READING

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