Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules.

@article{Facchinetti1997RegulatoryDO,
  title={Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules.},
  author={Vittorino Facchinetti and L Loffarelli and Sabine Schreek and Michael Oelgeschl{\"a}ger and Bernhard L{\"u}scher and Martino Introna and Jos{\'e}e Golay},
  journal={The Biochemical journal},
  year={1997},
  volume={324 ( Pt 3)},
  pages={
          729-36
        }
}
The A-Myb transcription factor belongs to the Myb family of oncoproteins and is likely to be involved in the regulation of proliferation and/or differentiation of normal B cells and Burkitt's lymphoma cells. To characterize in detail the domains of A-Myb that regulate its function, we have generated a series of deletion mutants and have investigated their trans-activation potential as well as their DNA-binding activity. Our results have allowed us to delineate the trans-activation domain as… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Myb protein specificity: evidence of a context-specific transcription factor code.

  • Blood cells, molecules & diseases
  • 2003
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED