Regulatory diversity of TUP1 in Cryptococcus neoformans.

  title={Regulatory diversity of TUP1 in Cryptococcus neoformans.},
  author={Hyeseung Lee and Yun C. Chang and Ashok Varma and Kyung J. Kwon-Chung},
  journal={Eukaryotic cell},
  volume={8 12},
Cryptococcus neoformans serotype A strains, the major cause of cryptococcosis, are distributed worldwide, while serotype D strains are more concentrated in Central Europe. We have previously shown that deletion of the global regulator TUP1 in serotype D isolates results in a novel peptide-mediated, density-dependent growth phenotype that mimics quorum sensing and is not known to exist in other fungi. Unlike for tup1Delta strains of serotype D, the density-dependent growth phenotype was found to… CONTINUE READING

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