Regulatory circuits of theamdS gene ofAspergillus nidulans

  title={Regulatory circuits of theamdS gene ofAspergillus nidulans},
  author={Michael J. Hynes},
  journal={Antonie van Leeuwenhoek},
  • M. Hynes
  • Published 2004
  • Biology, Engineering
  • Antonie van Leeuwenhoek
TheamdS gene codes for an acetamidase enzyme that hydrolyses acetamide to acetate and ammonium thus providingA. nidulans with a source of carbon and nitrogen. The exceptionally favourable genetics of this system combined with molecular analysis have enabled many regulatory circuits affectingamdS to be identified genetically. Characterization of the regulatory genes and the definition of the cis-acting sites involved have been done using bothin vivo andin vitro mutagenesis. Recent results on the… 
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Carbon catabolite repression in Aspergillus nidulans: a review
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Evidence is provided that the conversion of exogenous 2-pyrrolidinone to endogenous GABA requires a functional lamB gene, and that the expression of both lamA and lamB is subject to carbon and nitrogen metabolite repression in addition to amdR-mediated induction by omega-amino acids.
Pleiotropic mutants ofAspergillus nidulans altered in carbon metabolism
The results indicate that thecreB andcreC genes may have a regulatory role in the control of carbon catabolism.
Characterization of the amdA-regulated aciA gene of Aspergillus nidulans
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