Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients.

@article{Ke2000RegulatoryCP,
  title={Regulatory cells potentiate the efficacy of IL-4 gene transfer by up-regulating Th2-dependent expression of protective molecules in the infectious tolerance pathway in transplant recipients.},
  author={B. R. Ke and Thomas Ritter and Hirohisa Kato and Yuan Zhai and Jie Li and Manfred Lehmann and Ronald W Busuttil and H. D. Volk and Jerzy W. Kupiec-Weglinski},
  journal={Journal of immunology},
  year={2000},
  volume={164 11},
  pages={5739-45}
}
We have previously shown that the tolerant state in allograft recipients can be maintained and perpetuated by an "infectious" T cell-dependent regulatory mechanism. Hence, 1) treatment of LEW rats with RIB-5/2, a CD4 nondepleting mAb, produces indefinite survival of LBNF1 cardiac allografts; 2) donor-specific tolerance can be then transferred by spleen cells into new cohorts of test allograft recipients; and 3) putative regulatory CD4+ Th2-like cells are instrumental in this tolerance model. We… CONTINUE READING

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