Regulatory cascade controls virulence in Vibrio cholerae.

  title={Regulatory cascade controls virulence in Vibrio cholerae.},
  author={Victor J DiRita and Claude Parsot and Georg Jander and John J Mekalanos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={88 12},
Expression of more than 17 virulence genes in Vibrio cholerae is under the coordinate control of the ToxR protein. ToxR is a transmembrane protein that binds to and activates the promoter of the operon encoding cholera toxin. As yet, the ability of ToxR to activate directly other genes in this regulon has not been demonstrated. We have cloned a gene called toxT from V. cholerae 569B; the toxT gene product, like ToxR, can activate the ctx promoter in Escherichia coli. In addition, expression of… CONTINUE READING
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