Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?

Abstract

Advances in the treatment modalities for head and neck squamous cell carcinoma (HNSCC) over the last 20 years involving surgery, radiotherapy, chemotherapy, and immunotherapy are not fully reflected in increases in the 5-year survival rates, mainly due to locoregional recurrences and to a lesser extent, distant metastasis. This can, in part, be attributed to the fact that HNSCC induces severe depression of a patient's immune system. Recent advances in understanding the complex host-tumor interactions have led to the identification of a distinct suppressor cell population known as regulatory T cells that play a crucial role in maintaining T-cell tolerance to self-antigens. Here, we present a critical review of our understanding of the involvement of regulatory T cells in controlling the T-cell immune response in tumor occurrence and progression in HNSCC with an emphasis on current and future immunotherapeutic approaches involving regulatory T cells.

DOI: 10.1002/hed.20739
05001000200920102011201220132014201520162017
Citations per Year

2,511 Citations

Semantic Scholar estimates that this publication has 2,511 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Alhamarneh2008RegulatoryTC, title={Regulatory T cells: what role do they play in antitumor immunity in patients with head and neck cancer?}, author={Osama Alhamarneh and Shoba Maria Prescilla Amarnath and Nicholas David Stafford and John Greenman}, journal={Head & neck}, year={2008}, volume={30 2}, pages={251-61} }