Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.

@article{Wang2011RegulatoryTC,
  title={Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice.},
  author={Ying Wang and Geoffrey Camirand and Yan Lin and Monica Froicu and Songyan Deng and Warren D Shlomchik and Fadi G Lakkis and David M. Rothstein},
  journal={Journal of immunology},
  year={2011},
  volume={186 5},
  pages={2809-18}
}
Rapamycin (Rapa), an immunosuppressive drug that acts through mammalian target of Rapa inhibition, broadly synergizes with tolerogenic agents in animal models of transplantation and autoimmunity. Rapa preferentially inhibits conventional CD4(+) Foxp3(-) T cells (Tconv) and promotes outgrowth of CD4(+)Foxp3(+) regulatory T cells (Treg) during in vitro expansion. Moreover, Rapa is widely perceived as augmenting both expansion and conversion of Treg in vivo. However, most quantitative studies were… CONTINUE READING

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